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About this article Cite this article Pereira, M.J., Eriksson, J.W

Distribution The mean volume of distribution at steady state following a single 100-mg intravenous dose of sitagliptin to healthy subjects is approximately 198 liters

The combination of GIPR dominance and GLP-1R bias toward cAMP signals results in enhanced insulin secretion, improved metabolic parameters, and a more tolerable GI side effect profile 2,3,4