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Loren Pickart, who noticed that when plasma from young individuals was added to the liver tissue of older individuals, the older tissue would produce proteins more characteristic of younger individuals

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According to the US National Academy of Medicine, plasma -tocopherol concentrations less than 12 mol/L (516 g/dL) in adults are indicative of vitamin E inadequacy (2)

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However, the literature does not yet provide a fully resolved primary molecular target, a unified causal mechanism, or sufficient controlled human evidence to support conclusions about therapeutic use