Deamidation changes asparagine and glutamine residues, altering the molecule charge and function
It acts as an incretin and exerts a variety of physiological and pharmacological effects such as the promotion of insulin secretion [1]
While all are approved for obesity treatment, evidence specifically in post-bariatric populations varies considerably
doi: 10.1007/S00125-023-05962-Z/TABLES/1 125 BakAMEgefjordLGejlMSteffensenCStecherCWSmidtKet al
Quantitative real-time PCR was performed in 20 l of reaction mixture containing 1 l of cDNA, 10 pM of each primer ( Slc1a5 , Slc1a5 variant Gls1 , Gls2 , Cdkn2a , Cdkn1a , Cd38 , Igf1r , Il-1b , Il-6 and Il-10 ) and 10 l of SYBR Select Master Mix (Thermo Fisher Scientific) using Applied Biosystems 7500 Real-Time PCR System (Thermo Fisher Scientific)