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After ferroptosis, excess intracellular free iron can enter the mitochondria, resulting in smaller myocardial mitochondria, increased mitochondrial membrane density, decreased mitochondrial respiration, and mitochondrial membrane potential depolarization (Sumneang et al., 2020), thus inducing CD and a series of Cardiac Diseases such as arrhythmia (Wu et al., 2021a)

Nutrients 15 , 532 (2023)

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11 When filing an ANDA, an applicant must certify against every patent listed in the FDAs Orange Book for the RLD