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A $100 Million Trial Launched Today to Test Whether GLP-1 Drugs Plus Lifestyle Changes Can Prevent Dementia The Alzheimer's Association today launched a $100 million global clinical trial designed to answer one of the most consequential questions in aging medicine: can combining a GLP-1 receptor agonist drug with a proven lifestyle intervention actually prevent dementia

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Abbreviations DM: Diabetes mellitus TD1: Type 1 diabetes TD2: Type 2 diabetes DYRK1A: Dual Specificity Tyrosine Phosphorylation-Regulated Kinase 1A SIK: Salt-Inducible Kinase TGF-: Transforming Growth Factor- EGF: Endothelial Growth Factor GLP1: Glucagon-Like Peptide-1 CDK: Cyclin-Dependent Kinase GABA: -Amino Butyric Acid GLP1R: Glucagon-Like Peptide 1 Receptor GPCR: G ProteinCoupled Receptor hESC: Human Embryonic Stem Cells hiPSC: Human Induced Pluripotent Stem Cell IL: Interleukin NFAT: Nuclear Factor of Activated T Cells TGF: Transforming Growth Factor TNF: Tumor Necrosis Factor DPP-4: Dipeptidyl Peptidase-4 PPIs: Proton Pump Inhibitors References Abdolazimi Y, Zhao Z, Lee S, Xu H, Allegretti P, Horton TM, et al (2018) CC-401 promotes -cell replication via pleiotropic consequences of DYRK1A/B inhibition

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Wang Q, Hardie RA, Hoy AJ, van Geldermalsen M, Gao D, Fazli L, et al

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