incretin hormone glp-1 hormones and obesity - Alcaino - 2025 - The Journal of Physiology Incretins as Multi–Disease State Treatments

skin thickening or pits at the injection site (lipodystrophy)

If youre not obese, overweight with other medical conditions or have type-2 diabetes, you will need to look at alternatives

Instead, clinicians should acknowledge this risk and consider individualized risk-benefit strategies when prescribing GLP-1 RAs, particularly for patients with pre-existing ocular manifestations and must inform patients regarding possible ocular hazards while advocating for regular retinal examinations and assessments of visual acuity

Albert SG, Wood EM, Ahir V

The Rybelsus pill also requires significantly more active ingredient than shots, and that substance, semaglutide, is already in short supply

doi: 10.2337/db10-0098 176 StarichGHBarRSMazzaferriEL