Subgroup analyses found that curcumins antidepressant effects were duration-dependent: interventions over 8 weeks yielded significant benefits (SMD = 2.58, 95% CI: 4.54 to 0.61), whereas shorter courses (8 weeks) did not (SMD = 1.21, 95% CI: 2.59 to 0.17)
Full collagen remodeling takes longer, typically 12 to 16 weeks
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When the balance of these hormones is disrupted, it can lead to gut disorders such as inflammatory bowel disease and colorectal cancer
While the adverse events heterogeneity could be attributed to one particularly sensitive study, the remaining variability likely stems from methodological differences in study design, participant characteristics, and curcumin formulations (including bioavailability-enhancing technologies)
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