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For the main background medication subgroup analyses, the trial product estimand was used to reflect the effect of oral semaglutide versus each comparator without the confounding effect of rescue medication

In rodent GH pulse research, endogenous male GHRH produces GH pulses of ~25-40ng/mL amplitude every 3-4 hours (highly sex-dimorphic females have more irregular, lower-amplitude pulses)

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