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The pKa value determined for the cysteine persulfide is 4.34, suggesting that the persulfurated cysteine residue is present in a negatively charged deprotonated state, aligning with the robust electrostatic interaction observed in this investigation

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As a result, diabetes is now the leading cause of end-stage kidney disease in Western countries

2-3 , 500-700

9 The importance of the brain bioavailability of GLP-1 analogs is underscored by the prominent expression of the GLP-1R within the brain

This caution comes mainly from cosmetic formulators rather than from dermatology trials, and the evidence is limited, so it is not something to state as a hard rule