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You can use the Bristol Stool Chart to identify if you are experiencing constipation: Type 1: Separate, hard, nut-like lumps that are hard to pass

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For example, cell-free mtDNA is sensed by TLR9 in endosomes (recognizing CpG DNA) and by Cyclic GMP-AMP synthase (cGAS) in the cytosol (recognizing DNA in general), leading to production of inflammatory cytokines and interferons (1114)

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Hauber AB, Nguyen H, Posner J, Kalsekar I, Ruggles J