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INTRODUCTION Tirzepatide is a onceweekly glucosedependent insulinotropic polypeptide and glucagonlike peptide1 receptor agonist (GIP/GLP1 RA) recently approved by the US Food and Drug Administration (FDA) for the treatment of type 2 diabetes (T2D)

People see Ozempic's results, hear that retatrutide produced even larger reductions in trials, and assume combining them compounds the effect

By activating GLP-1 receptors in the brain, these medications help reduce feelings of hunger and regulate appetite signaling

GLP-1 medication can take several weeks to be effective

Kim KH, Son JM, Benayoun BA, Lee C