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Conclusions: No treatment-related TEEs were observed in the garadacimab clinical programme

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The unique T-1 hyperintensity on MR can help in narrowing the differential diagnosis

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These preclinical findings triggered regulatory caution: the FDA is not recommended during pregnancy

Key points to remember: GLP-1 receptor agonists are not known to cause memory loss based on current evidence Research into potential neuroprotective benefits is ongoing but remains investigational Memory problems in people with diabetes have multiple potential causes that require proper medical assessment If you have concerns about memory or cognitive function whilst taking any medication, discuss them with your healthcare provider for appropriate evaluation and management If you suspect you have experienced an adverse effect from a GLP-1 receptor agonist or any other medication, you can report this through the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)