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van Can et al

The approval was based on bioequivalence studies and clinical trial data previously conducted for Rybelsus

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The primary, evidence-based interventions for GLP-1 constipation are established in the broader constipation literature and recommended by clinicians: adequate fluid intake, gradually increased soluble fiber such as psyllium husk, regular physical activity, and osmotic laxatives such as polyethylene glycol when lifestyle measures are insufficient