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SIRT1s role in ferroptosis within brain injury is primarily through the regulation of cellular oxidative stress and iron metabolic balance

Kroner et al (49) demonstrated that elevated iron levels in microglia promote phagocytosis and drive a harmful M1 phenotype, which triggers the release of pro-inflammatory factors such as TNF-, IL-1, IL-6 and nitric oxide (NO), causing neuronal damage

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Front Cell Neurosci

Supports overall systemic recovery and adaptability