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Nugent NR, Tyrka AR, Carpenter LL, Price LH

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Consider lowering the dose of these agents when coadministered with FARXIGA Pooled safety data across 12 placebo-controlled clinical studies of glycemic control in adults with T2D 1 Adverse reactions reported in 2% of adults taking FARXIGA 10 mg (n=1193) vs placebo (n=1393) included female genital mycotic infections (6.9% vs 1.5%), nasopharyngitis (6.3% vs 6.2%), UTIs (4.3% vs 3.7%), back pain (4.2% vs 3.2%), increased urination (3.8% vs 1.7%), male genital mycotic infections (2.7% vs 0.3%), nausea (2.5% vs 2.4%), dyslipidemia (2.5% vs 1.5%), influenza (2.3% vs 2.3%), and discomfort with urination (2.1% vs 0.7%)

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In the SURPASS clinical trial program evaluating tirzepatide for type 2 diabetes and the SURMOUNT trials for weight management, insomnia was not identified as a statistically significant adverse event compared to placebo groups, based on published trial results