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Therefore, the ratio of oxidised and reduced glutathione indicates the redox state of a cell and may represent a valuable tool for the assessment of oxidative stress and a target for drug-based antioxidant therapies [4]

McKenna, M

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Activators and inhibitors of NRF2: a review of their potential for clinical development

Manipulation of intracellular GSH pools by supplementation with GSH precursors was found to block induction of JNK activity by methylating agents [26] Similarly p53 function has been reported to be redox sensitive, primarily through in vitro modification of its cysteine residues [27]

In this section, for both control and rd1 we present the grouping case with best outcome, that is high goodness of fit value for [GSH] and for [GSSG]