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doi: 10.1016/j.fct.2012.08.031 304 Grian-LisonCBlaya-CnovasJLLpez-TejadaAvalos-MorenoMNavarro-OcnACaraFEet al

Advanced symptoms of Parkinsons disease include: Uncontrollable shaking and tremors Reduced ability to chew and swallow Difficulty enunciating words Impaired ambulation and frequent falls Bent-over posture rinary and fecal incontinence nability to perform activities of daily living (ADL) like dressing, bathing, and eating As Parkinsons approaches its end game, palliative care and hospice with pain management are the final treatment approaches

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In addition, a previous report has suggested a detection tool targeting increased GLP- 1R expression in early lesions of MEN1 pancreas [24]