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It engages the same amylin/calcitonin receptors in the same hindbrain area postrema as native amylin and pramlintide, 5 11 and it drives the same vagally mediated slowing of the stomach that Samsom and colleagues quantified for pramlintide
Liu JL, Hlavka JP, Hillestad R, Mattke S
You can check out their YouTube channel for deeper dives into related subjects
Prioritize protein (0.7 to 1.0 grams per pound of target body weight), eat frequent small meals rather than large infrequent ones, limit high-fat foods during dose increases to reduce nausea, stay hydrated, and avoid alcohol (which worsens both GI side effects and calorie intake)
Within 1-2 weeks , users tend to notice increased mental clarity, increased calmness, and reduced stress
It decreases COX-2 gene expression, reduces myeloperoxidase activity, and lowers pro-inflammatory cytokines including IL-6 and TNF-alpha
