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Its effects on the gut-joint axis may provide additional benefits, as intestinal inflammation is increasingly recognized as a contributor to systemic inflammatory conditions including arthritis

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By inhibiting NNMT, 5-Amino-1MQ increases cellular SAM and NAD+ levels, enhances NAD+ salvage pathway flux, activates SIRT-1, boosts oxidative phosphorylation (OXPHOS), and influences cellular energy homeostasis and epigenetic modifications