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Based on this assumption, many physicians and endocrinologists believe that the normalization of TSH with a T4 preparation demonstrates adequate tissue levels of thyroid, perpetuated by practice guidelines indicating T4 monotherapy as the standard of care

TRPA1 underlies a sensing mechanism for O2

Starting both agents at lower doses than typically used for monotherapy and escalating more slowly can improve tolerability

How providers apply that distinction is a clinical decision made for individual patients

PubMed, Trinder, M., et al