doi:10.1016/j.bioorg.2020.104492 17
Mass spectra were scanned in the range of 401,000 amu
Indications: attention-deficit disorders narcolepsy Contraindications: Lactation Contraindicated for long-term use for treating obesity (due to development of tolerance &/or drug dependence) Side Effects: anorexia dry mouth dizziness headaches hyperpyrexia hypertension insomnia nervousness palpitations / tachycardia weight loss Black Box Warnings: HIGH POTENTIAL FOR ABUSE Pharmacokinetics: Dexedrine - PO, completely absorbed in 3 hr
Another warning this time from history Writing in the British Medical Journal in 1998, Abi Berger, a general practitioner, noted: "It must surely be every drug company's dream: to have a product so sexy that the need for marketing and public relations has been obviated by a tidal wave of media hype." It's as if the hype around GLP-1 agonists is a case of "history repeating"
TMAO not only induces endothelial dysfunction but also acts on various cell types, such as endothelial cells, epithelial cells, vascular smooth muscle cells, nerve cells, and pancreatic cells, triggering multiple cell death mechanisms, including necrosis and programmed cell death, thereby influencing host health
AfonsoReis et al
