Gradual discontinuation may reduce rebound effects compared to abrupt cessation
Whether that multiple is justified depends entirely on whether the research question requires glucagon receptor engagement or whether the 4.3 percentage point weight loss advantage over tirzepatide (24.2% vs 20.9%) is scientifically meaningful for the study design
It requires: Proper medical evaluation Individualised dosing Nutritional and protein support Muscle preservation strategies Ongoing monitoring When used without structure, results can be suboptimal
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P., Klingenberg, L., Astrup, A., & Sjdin, A