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Li T, Chen ZJ

This selective mechanism of action makes Ipamorelin more precise and safe in regulating growth hormone levels

produced a sustained IGF-1 elevation (40-50% above baseline for 14 days) without recapitulating the pulsatile GH architecture

These agents target various inflammatory cytokines and their receptors, including IL-17 and IL-12/23 (Garcia-Prez 2013

If side effects emerge during dose increases, clinicians may consider reverting to the previously well-tolerated dose and then gradually reintroducing titration, or alternatively, establishing a maximum tolerated dose for continued therapy

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