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Aging disrupts this process through cell cycle arrest mediated by p53 and p21, which halt hepatocyte proliferation, particularly in chronic injury or disease

Tirzepatide alters gut microbiome composition indirectly through changes in gastric emptying, intestinal transit, and caloric intake

Liraglutide ameliorates diabetic kidney disease by modulating gut microbiota and L-5-Oxoproline

PLoS One 2019;14:e0224549.ArticlePubMedPMC 17

Cell Death Dis 10 , 321 (2019)

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