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Are there any medical issues that would prevent someone from taking GLP-1s

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After 72 weeks, patients who received up to 6 mg of orforglipron averaged a weight loss of 5.5%, those who received 12 mg averaged 7.8%, and those who received 36 mg averaged 10.5%, while the placebo group averaged just 2.2%

Andersson L, Halenius A, Pulkkinen L, et al

Adjust your meal schedule Eating small meals throughout the day is best

The answer about Tylenol & alcohol is more complicated than you might think: The warning label on the Tylenol PM Extra Strength label is confusing to me: It offers a liver warning that states: Severe liver damage may occur if you take 3 or more alcoholic drinks every day while using this product We hesitate to draw conclusions from such a warning, but some people might assume that if they only take 2 alcoholic drinks daily they would not risk liver damage