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ROS induces epithelial-mesenchymal transition via the TGF-1/PI3K/Akt/mTOR pathway in diabetic nephropathy

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We therefore extended our observations to the KK-Ay mouse, a mouse model of spontaneous obese T2D, which is a product of crossbreeding between obese KK and lethal agouti yellow (Ay) mice and carries heterozygous mutation of the agouti gene (52)

2 Glucagon-like Peptide-1 (GLP-1) GLP-1 is primarily produced in the enteroendocrine L cells in the small intestine and colon, although pancreatic alpha cells produce small quantities as well