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The participant characteristics are first summarized, followed by detailed efficacy results, exploratory analyses, and safety monitoring data [2]

Researchers continue to investigate these mechanisms as part of broader studies examining regenerative biology and cellular resilience

1998;336(Pt 3):535539

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For breeding, male VE-Cadherin-Cre ERT2 mice were crossed with female Igf1r f/f mice to generate VE-Cadherin-Cre ERT2 /Igf1r + / males, which were subsequently bred with Igf1r f/f females to establish the VE-Cadherin-Cre ERT2 /IGF1R homozygous floxed founder colony, following our previously described protocol [17, 45]