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Co-enzyme B12 also interacts with the enzyme methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase), required for the conversion of homocysteine to methionine, which is essential for folic acid metabolism and the formation of thymine, which is a component of DNA

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Regression coefficients and odds ratios across outcomes, for the full cohort and stratified by pre-existing diabetes mellitus

[18] [19] Long-term use of proton pump inhibitors or H2-receptor antagonists can also impair B12 absorption