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Concretely, the beneficial commensal genera decreased, including FP (226, 227), Clostridiaceae , Rikenella , Bacteroides , Prevotella , Roseburia , Pseudobutyrivibrio , Escherichia/Shigella , and Raecalibacterium (228), whereas the pathobiont genera rose, including Lactobacillus (229), Ruminococcus , Akkermansia , Bifidobacterium , Fusobacterium , Erwinia , and Streptococcus (230, 231)

In some studies, tirzepatide achieved up to 20% body weight reduction, while semaglutide users averaged around 15%

The European Union has also formulated guidelines for the safety assessment of plant extracts as food additives and audited the functional claims, raising the threshold for market entry while ensuring safety (251)

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As around This blockbuster class of medications includes semaglutide (Ozempic, Wegovy), tirzepatide (Zepbound, Mounjaro), and liraglutide (Saxenda)

Semaglutide works by slowing gastric emptying and signaling your pancreas to release insulin only when blood glucose risesa mechanism that begins within 24 hours of injection but takes weeks to produce visible metabolic changes