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[DOI] Longo M, Paolini E, Meroni M, Dongiovanni P

Conversely, those with genetic variants associated with slower response may maintain stable blood pressure readings longer, reducing immediate adjustment urgency

Reference: Michiels C et al

Blood flow to the kidneys can be reduced by hemorrhage, dehydration, heart failure, pulmonary embolism, sepsis (a systemic inflammatory response caused by infection of the blood), excessive blood calcium, and some drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs) (Ferri 2014a)

These substances can create oxidative stress, harm mitochondria, and even damage DNA

This contributed to a higher discontinuation rate for tirzepatide (13.2% vs 10.1%)