Together, the two studies point toward a more nuanced understanding of how GLP-1 drugs work, and who benefits most
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Participants randomized to retatrutide initiated treatment with 2 mg once weekly and increased the dose in a stepwise approach every four weeks until reaching the target dose of 9 mg (via steps at 2 mg, 4 mg, and 6 mg) or 12 mg (via steps at 2 mg, 4 mg, 6 mg, and 9 mg)
(13) A key mechanism through which GLP-1 receptor agonists may influence bone metabolism is the osteoprotegerin (OPG)/RANKL/RANK pathway, which regulates osteoclast differentiation and bone resorption
SeekPeptides will update this guide when the trial results become available, providing an independent analysis of whether the data supports the product claims
This cuts total time to 6 months versus the standard 9 months