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Could they have started out with some realistic parameters which they subsequently felt the need to abandon because they had fallen several months behind their two-year recruitment phase goal to enlist 360 dogs with enlarged hearts

clinical data is thin

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The Endocrine Society's 2023 clinical practice guidelines on obesity pharmacotherapy note that "the absence of safety data in humans should not be conflated with a safety guarantee, particularly when preclinical mechanisms suggest CNS activity" [11]

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