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isocitrate dehydrogenase, -ketoglutarate dehydrogenase, and succinate dehydrogenase, and at the same time reduced generation of reactive oxygen species stabilized the mitochondrial membrane potential, enhanced the levels of ATP, and enhanced the activity of the mitochondrial complex I [94]

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Kalyesubula R, Perazella MA (2011) Nephrotoxicity of HAART

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Helps reduce occasional bloating

If the priority is glycaemic control or cardiometabolic health, then moderate dosages like 4 mg or 8 mg might already offer the majority of the benefit without excess side effect burden