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GLP-1 medications slow gastric emptying, which could theoretically affect the absorption of some oral psychiatric medications

For instance, a meta-analysis demonstrated that SGLT2i/GLP-1 RA combination therapy lowered the incidence of HF and major adverse cardiac and cerebrovascular events more effectively than either agent alone [96]

Among AOMs, prescribing increased substantially in September 2024 compared to June 2024 (+32.3%)

In June 2025, the World Health Organization warned that semaglutide medications such as Ozempic may rarely cause NAION and advised patients to seek immediate medical care after rapid eyesight changes

This guide compares the two on mechanism, efficacy, approval status, cost, and side effects, then explains which one fits which situation

Clinical trial data shows this dose produces approximately 20 percent average weight loss over 72 weeks