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For example, the ionizable lipid material DAL4-LNP containing diaminic groups of different head groups (DAL) can efficiently deliver different mRNAs to tumor cells, and intratumoral injection of DAL-LNPs loaded with IL-12 and IL-27 mRNA can induce CD8 + T cell infiltration into tumors and significantly inhibit tumor growth compared to IL-27 and GM-CSF mRNA monotherapy (145)

Adding 1 mL gives 10 mg/mL, and adding 2 mL gives 5 mg/mL

The IRO is binding on Anthem

PMID: 3522621

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