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Epigenetic and Cellular Reprogramming: By blocking NNMT-mediated methylation of nicotinamide, preserves NAD salvage pathway activity, increases SIRT-1 signaling, reduces histone deacetylation, and promotes metabolic reprogramming toward oxidative phosphorylation and glycolysis balance, supporting tissue repair and energy homeostasis 1-4

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The COMT gene catechol-O-methyltransferase helps to break down and expel substances that have a catechol structure

Mittra B., Zamudio J.R., Bujnicki J.A., Stepinski J., Darzynkiewicz E., Campbell D.A., Sturm N.R., "The TbMTr1 spliced leader RNA cap 1 2'-O-ribose methyltransferase from Trypanosoma brucei acts with substrate specificity", J Biol Chem 6: 3161-3172 (2007)