For first-time users, the published evidence base is strongest on topical at 1 to 2%
P.AktolunM.et al (2024b)
Orally, subcutaneously, or topically, depending on clinical goals
Chitosan is widely used in mucosal drug delivery due to its excellent biocompatibility, biodegradability, low toxicity, and relatively low cost
Along the same lines as ivacaftor and hypertonic saline, several pharmaceutical groups have been pursuing pharmaceuticals that target other ion channels to improve mucociliary clearance in a cftr -independent manner
These may include: Temporary soreness, redness, or swelling at the injection site Mild flushing (particularly due to niacin, or vitamin B3) Occasional lightheadedness or mild nausea, which typically passes quickly Adverse reactions are uncommon, especially when administered by trained medical professionals