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Inflammation of the pancreas (pancreatitis): contact your healthcare provider immediately if you have severe pain in your abdomen that will not go away, with or without nausea or vomiting

Long-term use is tolerable because the medication works with your body's natural regulatory pathways rather than against them

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Another study used a genetic loss of function mouse model to delete the GLP-1R in vagal afferent/effect nerves ( Phox2b-Cre Glp1r flox/flox ) (Sisley et al., 2014)

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Nausea management strategies Nausea is the most commonly reported side effect across all dose levels