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R., Hancock, R

As inflammation begins to resolve, macrophages undergo a shift from M1 to M2 phenotypes, fibroblasts become activated and initiate extracellular matrix remodeling, and coagulation abnormalities promote a hypercoagulable state

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Vomiting This occurs less frequently than nausea but is reported by approximately 25 percent of patients at some point during treatment

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Its main physiological roles include stimulating insulin release in a glucose-dependent manner, suppressing glucagon, slowing gastric emptying, and reducing appetite