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Although the progression of neurologic complications is generally gradual, such symptoms may not be reversed with treatment of vitamin B 12 deficiency, especially if they have been present for a long time

And then the gut brain access, you guys has significant overlap with the hypothalamic pituitary adrenal axis, right, which is one of the other main axes of the autonomic nervous system, which also has overlap with the trigeminal cervical complex, which starts at about C2 in the spinal column and goes up into the brain connected by the trigeminal nerve

So I think the promise here is a medication that gives us moderate weight loss, which is sufficient in the majority of our patients to improve their health, to meet our patients needs for weight loss, to meet our health goals in terms of preventing and treating obesity-related complications with a well-tolerated medication

It felt like a sharp throbbing pain on one side of my head behind my eye