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The presence of comorbidities can significantly impact the pharmacokinetics of Vitamin B12, making it essential to adjust dosing protocols. Expert Opinion on Vitamin B12 Therapy Genetic Factors Affecting B12 Metabolism Genetics play a role in how well someone can use Vitamin B12

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The washout allows receptor resensitization while newly formed mitochondria continue operating at baseline

The hormone breaks down quickly in the body, limiting its therapeutic potential in native form