Mechanism is fundamentally different from GLP-1 receptor agonists phentermine acts on the central nervous system as a stimulant, whereas GLP-1 receptor agonists act on hormone-receptor pathways governing appetite and glucose
In particular, NRF2 exhibits the capacity to regulate the expression of multiple target genes, including GPX4 and SLC7A11, within the SLC7A11-GPX4-GSH pathway
1 Since the late 1980s, however, the triumvirate has expanded to include additional core defects
Another factor that may contribute to Nrf2 persistent activation in tumour cells is the activation of p62, a multifunctional protein involved in selective autophagy and often overexpressed in tumours [6]
10.1039/b500409h 217 ParnhamM
Summary: Towards Personalized Management in OSA OSA remains a major health concern for millions of people