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124 In addition to these well-established categories, recent studies have revealed metabolic biomarkers (e.g., glucose transporters and lactate dehydrogenase), epigenetic modifications (e.g., DNA methylation patterns and histone modifications), and key signaling pathway components (e.g., Wnt/-catenin, Notch, and Hedgehog) that are critical for CSC maintenance and plasticity

Metabolic regulation of macrophage activation

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Notably, a dual-targeted, -helical bicycle synthesized via this method exhibited potential as a cytotoxin for cancer treatment