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Compounds to Avoid DSIP should not be combined with sedative medications, benzodiazepines, or other CNS depressants without medical supervision

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Acknowledgements Work discussed in this Review was supported by a Wellcome Trust Senior Investigator Award (095531), the Knut and Alice Wallenberg Foundation, the Swedish Research Council, the Hartwell Foundation for Biomedical Research (201500731), the Juvenile Diabetes Research Foundation (CDA-2-2013-54) and the US NIH (DK110276)

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2 These numbers should set realistic expectations: measurable structural change in 12 weeks of consistent use, with improvements continuing over 36 months

Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation