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If the answer is no, consider a slight increase in dose (titration) or a change in timing before abandoning the compound

Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats

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10.1021/acsnano.3c05261 40 FengZ.HuangJ.FuJ.LiL.YuR.LiL

A number that looks impressive on a label isn't the same as a number that behaves well on skin