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This suggests that the joint is exposed to circulating GLP-1, but only to a limited extent under physiological conditions

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Compared with SIMS imaging, MALDI-MSI is relatively gentler, generating minimal fragmentation, and is therefore suitable for in situ detection and imaging of intact proteins

The free apo-peptide binds copper(II) with high affinity through its N-terminal amine, the histidine imidazole nitrogen, and the deprotonated amide nitrogen, forming the GHK-Cu species that figures in much of the published literature