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Furthermore, hyperhomocysteinemia increases the risk of an ischemic stroke by inhibiting the endogenous anticoagulant system and increasing thrombin production (Faverzani et al
Thus, clinical guidelines suggest parenteral anticoagulation for at least 5 days before starting dabigatran or edoxaban
There is a huge gap between the reported incidence of side-effects in the medical literature most of the studies sponsored by the drug manufactures and the apparent prevalence in the general population
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