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TYS of CCK-8 inserts into the hydrophobic pocket formed by P114 2.64 , F120 ECL1 , and Q204 ECL2 in CCK2R (CCK2R-TYS-pocket), while inserting into the pocket formed by N98 2.61 , P101 2.64 , N102 2.65 , K105 2.68 , T186 ECL2 , R197 ECL2 , and M195 ECL2 in CCK1R (CCK1R-TYS-pocket)

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