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References: Yakar, S et al., 40 YEARS OF IGF1: Insulin-like growth factors: actions on the skeleton (Jul 2018)
Association of increased serum lipopolysaccharide, but not microbial dysbiosis, with obesity-related osteoarthritis
TPEN exhibits the highest affinity for zinc compared to other chelators (Ka = 1015.58 M 1 )
In practice, that same additive quality is also the main risk: two strong satiety agents together can suppress appetite and slow the gut more than intended, which is why tolerability not maximum weight effect tends to be the limiting factor in any amylin-plus-incretin discussion
It increased corneal nerve fiber density and improved sensory pain thresholds, suggesting its role as a disease-modifying agent