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has demonstrated that obesity increases the production of soluble UA mediated by gut dysbiosis, contributing to accelerating resorption of alveolar bone in periodontitis, which processes could be blocked by allopurinol, a xanthine oxidase inhibition (104)

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Enhanced expression of defense-related genes like GSTs during systemic infections could be also due to the silencing suppressor activity of the infecting virus, as shown for A

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